Cadherin 1 (CDH1), CDKN2A, the runt‐related transcription factor 3 (RUNX3), BRCA1 and RASSF1A are reported to be suppressed by DNMT3B‐dependent DNA hypermethylation in gastric or breast cancers [51, 52]. The gene discussed is CDKN2A; the disease is breast cancer.