Although we have previously established highly metastatic derivatives of pancreatic cancer cells using a similar strategy [42], the expression level of DNMT was not increased in highly metastatic derivatives of pancreatic cancer cells (GSE107960), suggesting that the interactions between cancer cells and the renal microenvironment may be crucial for the upregulation of DNMT3B. The gene discussed is DNMT1; the disease is familial pancreatic carcinoma.