115 Pfisterer Pfisterer M M Buser Buser P P Rickli Rickli H H Gutmann Gutmann M M Erne Erne P P Rickenbacher Rickenbacher P P BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial JAMA JAMA 2009 2009 301 301 4 4 383 383 392 392 19176440 19176440 115. Here, NPPB is linked to heart failure.