MAP2K7 and ovarian carcinoma: Once activated the receptor suffers auto phosphorylation of its tyrosine-kinase intra-cytoplasmic domain there in cascade activate the RAS/RAF/MEK/MAPK and therefore the nuclear transcription factors by activation and regulation of genes responsible for cellular replication, angiogenesis, differentiation, etc. Expressed in lung, colon, breast, head and neck, ovarian cancer, pancreas, bladder and kidney tumors12,.26