REN and inborn error of immunity: In particular, we detected that ZAP70 was enriched in primary immunodeficiency, TNFRSF4, and CXCL5 were enriched in cytokine-cytokine receptor interaction, CTSG was enriched in the renin-angiotensin system, and the CHRM2 and CTSG were enriched in neuroactive ligand-receptor interaction (Figure 8).