Common prostatic diseases other than typical benign lesions, such as acinar adenocarcinoma, BPH and prostatitis, are usually inert or chronic, with varying degrees of elevated serum PSA levels or disturbing symptoms such as lower urinary tract symptoms (LUTS), and interfere with the quality of life as a long-term problem for males, particularly elderly males, as BPH and prostate cancer are age-related conditions [6]. Here, KLK3 is linked to benign prostatic hyperplasia.