CTNNB1 and colorectal carcinoma: Supportive of this hypothesis, previous findings also reported an increased prevalence of somatic mutations in CTNNB1 among individuals with CRC who were younger than age 30 years and the highest proportion of consensus molecular subtype-1 (CMS-1; ie, microsatellite instability immune subtype) among individuals with CRC who were younger than age 40 years.50,51