Another study that supports this notion is the study by Billet et al. who demonstrated that administration of enoxaparin, unfractionated heparin, and apixaban to severe cases of COVID-19 reduced the mortality rate, most probably due to lower thromboembolic complications, while it could be acceptable to postulate a role of inhibiting heparanase activity in these patients [75]. Here, HPSE is linked to COVID-19.