PKD1 and polycystic kidney disease: Heterozygous PKD1 variants are the most common cause of adult‐onset autosomal dominant polycystic kidney disease, while biallelic PKD1 variants are associated with early and potentially neonatal‐onset, severe polycystic kidney disease (Al‐Hamed et al., 2019; Audrézet et al., 2016; Durkie et al., 2021).