In addition, it has been shown that SARS‐CoV‐2 reduces the ACE2 expression, which is an interesting contradiction, since ACE2 has been described as the main receptor mediating virus internalization.[14] The cooperation with RGD‐binding integrins expressed on human airway epithelial cells (including αVβ3, αVβ5, αVβ6 and αVβ8) may explain this evidence: the RGD motif in the spike protein of SARS‐CoV‐2 may promote viral infection in low ACE2‐expressing cells,[15] accordingly to the second hypothesized mechanism cited before. The gene discussed is ACE2; the disease is viral infectious disease.