TIPS placement exerted beneficial effects on RAAS and sympathetic activity115 and significantly reduced HRS incidence in patients with refractory ascites (9% vs. 31% receiving LVP and albumin)116 and thus is an interesting treatment option to prevent and treat HRS-NAKI (that is, former type 2), which typically is associated with recurrent or refractory ascites117. This evidence concerns the gene ALB and Ascites.