FN1 and neoplasm: During tumor progression, transcription factors of the SNAIL, TWIST, and ZEB gene families give rise to the EMT transcriptional program, which is characterized by the detachment from the epithelial basement membrane (BM) and the acquisition of a β1/β3 integrin and FN-driven migratory phenotype, endowing cancer cells with increased invasive ability and resistance to therapies77.