On a related note, within the proneural and classic subgroups of patients with GBM, a subpopulation exists in which high αvβ3 integrin levels activate a PAK4-mediated YAP/TAZ signaling pathway that in turn enhances the expression of the insulin-regulated and neuron-specific glucose transporter GLUT3. This evidence concerns the gene SLC2A3 and glioblastoma.