In vitro, CAFs isolated from human tumors produce and polymerize—via coordinated α5β1/αvβ3 integrin-binding and platelet-derived growth factor receptor alpha (PDGFRα)-mediated actomyosin contractility—an abundant anisotropically oriented FN fibrillar network along which cancer cells migrate directionally in an αv integrin–dependent manner87,88. Here, PDGFRA is linked to cancer.