AIF1 and neoplasm: Morphometric analysis of intratumoral Iba-1+ cells revealed that normal canine brain demonstrated the homogeneous distribution of Iba-1+ cells with a small cell body and several branched processes, consistent with a ramified morphology (Figure 2A).27 Conversely, GAM morphology across tumor grades reflected a larger cellular population lacking the typical ramified morphology (Figure 2).