Several studies have demonstrated that the survival of patients with GBM is affected by age, KPS, extent of resection, and chemoradiotherapy with TMZ.1,2,22,23 The relationship of age in GBM IDH-WT has been confirmed by studies with comprehensive genetic characterization.6,10 Our results further confirmed that younger age and chemoradiotherapy with TMZ improved OS in GBM IDH-WT. This evidence concerns the gene IDH1 and glioblastoma.