In our previous study, we assessed the effect of LF on HT29 cells both in vitro and in vivo, and found that LF effectively suppressed angiogenesis in HT29 tumor by regulating the VEGFR2/VEGFA/PI3K/Akt/Erk1/2 pathway (Li et al., 2017). This evidence concerns the gene MAPK3 and neoplasm.