Recent studies showed the effects of FTO77, protein arginine methyltransferase 1 (PRMT1) 78, coactivator associated arginine methyltransferase 1 (CARM1)/PRMT4 79, Otubain-2 (OTUB2) 80, RING finger protein 144A (RNF144A) 81, plant homeodomain finger protein 20-like protein 1 (PHF20L1) 82, heat shock transcription factor 1 (HSF1) 83, epithelial cell transforming sequence 2 (ECT2) 84, pescadillo homolog 1 (PES1) 85, PHACTR2-AS1 (PAS1) 86, breast cancer-related transcript 1 (BCRT1) 87, and circCDYL 88 on progression of breast cancer and they provided novel therapeutic targets. Here, OTUB2 is linked to breast cancer.