GLP-1RAs, such as lixisenatide, not only rely on β-cell function and glucagon suppression, but also assist to lower glucose by other (insulin-independent) mechanisms such as delayed gastric emptying, underlying the clinical utility of GLP-1RAs as adjuvant therapy to basal insulin in longstanding T2DM 14. The gene discussed is GCG; the disease is type 2 diabetes mellitus.