The overexpression of fibulin‐5, a multifunctional extracellular matrix (ECM) protein encoded by the FBLN5 gene, induced apoptosis in human colorectal cancer HT‐29 and SW480 cells by enhancing the phosphorylation of p38 and ERK and alleviating the level of p‐Akt by downregulating TRPV1 88. This evidence concerns the gene FBLN5 and colorectal cancer.