To assess the requirement for MET in SH3PXD2A-AS1-induced CRC malignant characteristics, we inhibited MET expression by MET inhibitor (SU11274) in HCT116 cells overexpressing SH3PXD2A-AS1 or increased MET expression by using MET plasmid in SH3PXD2A-AS1 knockdown HCT116 cells. This evidence concerns the gene PTGDR and colorectal carcinoma.