To investigate the role of GABABR, we first found that the expression of GABABR1 in tumor tissues was significantly lower than those in normal adjacent tissues from patients with CRC by using immunohistochemistry Compared with the normal adjacent tissues, the rate of GABABR1 positive cells (5%) was decreased in tumor tissues (Figure 1A). The gene discussed is GABBR1; the disease is colorectal carcinoma.