To further evaluated the role of Hippo/YAP1 signaling in the GABABR1 down-regulation impaired biological phenotype of colon cancer cells in vivo, we constructed a colon cancer Xenograft mice model via subcutaneous injection of normal or GABABR1 knockdown Lovo cells with or without Peptide 17 treatment. This evidence concerns the gene YAP1 and colonic neoplasm.