CDH2 and colorectal carcinoma: To further explore whether Activation of Hippo/YAP1 signaling contributes to the GABABR1 down-regulation activated EMT in CRC cells, we then evaluated the mRNAs (Figure 5A) and protein (Figure 5B) levels of EMT-related genes, including E-cadherin, N-cadherin, and Vimentin.