SiRNA-mediated knockdown of PKM2 resulted in an upregulation of tumor suppressors, including Bad, caspase 7, and E-cadherin, whereas oncogenes, such as MMP-2, MMP-9, HIF1α, and VEGF, were downregulated in the SK-OV-3 cells 14. The gene discussed is CASP7; the disease is neoplasm.