Moreover, we also found that K374 mutation of ATG9B still can interact with MYH9 (Fig. S6E) and does not enhance invasive ability of ATG9B in CRC, compared with WT-ATG9B (Fig. S6F), indicating that the function of K374R-ATG9B is as same as WT-ATG9B because K374 mutation might not affect ATG9B–MYH9 interaction. The gene discussed is ATG9B; the disease is colorectal carcinoma.