According to the number of variants reported per gene, most variants were captured in LEP, with eight obesity-associated variants reported among Arabs (rs11761556, rs7799039, c.104 T > G, c.34delC, rs104894023, rs1349419, rs2167270, and tetranucleotide repeat (TTTC) n) from 7 studies that were conducted in two Arab countries (Tunisia and Egypt) (Table 1, Table S3). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.