TP53 and colorectal carcinoma: CRC arises from an association of genetic and environmental factors, and it has been identified as involving multiple cell signaling pathways, such as Wnt, epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK), tumor protein 53 (TP53), phosphoinositide 3-kinase (PI3K), and transforming growth factor beta (TGFβ)/SMAD4,5.