First, in order to examine whether the score reflect adipogenesis in patient breast cancer, we investigated the association of the score with several adipogenesis-related genes (Acetyl-CoA carboxylase/ACLY, ATP citrate lyase/ACACA, NADP-dependent malic enzyme/SLC25A10, and mitochondrial dicarboxylate carrier/ME1) and adipocyte-related genes (adiponectin/ADIPOQ, leptin/LEP, lipoprotein lipase/LPL, and perilipin1/PLIN1) in the GSE96058 and TCGA cohorts. This evidence concerns the gene ACLY and breast cancer.