Specifically, the most relevant cytokines that were significantly associated with mortalityin COVID-19 patients are: IFN-β (HR 2.18; 95% CI 1.49, 3.21; p < 0.001), IL-13 (HR 2.11; 95% CI 1.52, 2.93; p < 0.001), TNF-β (HR 1.79; 95% CI 1.35, 2.37; p < 0.001), TGF-α (HR 1.27; 95% CI 1.09, 1.49; p = 0.03), and IL-18 (HR 0.76; 95% CI 0.62, 0.92; p = 0.049) (Supplementary Table 8b). The gene discussed is TGFA; the disease is COVID-19.