In addition, various mutations in the CSF3R have been reported in myeloid disorders including, chronic neutrophilic leukaemia (CNL), myelodysplastic syndrome (MDS), Acute Myeloid Leukaemia (AML), and atypical chronic myelogenous leukaemia (aCML)55, which confirmed the importance of this receptor in neutrophil differentiation. This evidence concerns the gene CSF3R and atypical chronic myeloid leukemia, BCR-ABL1 negative.