Here we extend upon this work and identify the LIM and SH3 domain protein 1 (Lasp1), a tumour-associated adaptor molecule originally cloned from metastatic breast cancer8,9, not only as part of one epigenomic cluster associated with autonomously aggressive RA-FLS, but also as one prominent epigenetic mark in two different animal models of the disease. The gene discussed is LASP1; the disease is neoplasm.