In addition, our data showed that IL-6 promotes the interaction between BECN1 and JAK2 and enhances BECN1 tyrosine phosphorylation at Y333, suggesting that the JAK2-dependent phosphorylation of BECN1 is the mechanism by which IL-6 promotes autophagy in colorectal cancer and underscoring the importance of autophagy promotion by IL-6/JAK2 signaling. This evidence concerns the gene IL6 and colorectal cancer.