USP35, encoding Ubiquitin Specific Peptidase 35 (USP35), is located on chromosome 11q14.1, where a small amplicon including the four genes GAB2, USP35, KCTD21, and ALG8 was amplified around 9% in breast cancer patients (www.cbioportal.org) [18]. The gene discussed is USP35; the disease is breast cancer.