To investigate the potential regulatory role of Prrx1 in glioma, the gene set enrichment analysis (GSEA) was performed in multiple GEO datasets and the results showed that pathways related to stem cell (Fig. 1H) and angiogenesis (Fig. 1I) were positively enriched in patients harboring high Prrx1 expression. Here, PRRX1 is linked to glioma.