Furthermore, to investigate the functional miR-155-5p-HuR binding of seeding AU-rich elements (AREs) sequence on the stability of IGF1R transcripts, angomiR-155-5p or antagomiR-155-5p transfected RCC cells were further treated with ActD, and meanwhile transfected with wild-type 3’-UTR or mutant type, respectively. The gene discussed is IGF1R; the disease is renal cell carcinoma.