Moreover, miR-103 promotes HCC cell proliferation and migration in the simulation transition zone of RFA through the PI3K/Akt signalling pathway by targeting PTEN [36], promotes the metastasis and EMT of HCC by directly inhibiting LATS2 [37], and regulates HCC growth by targeting AKAP12 [38]. The gene discussed is PTEN; the disease is hepatocellular carcinoma.