It is important that these binding patterns were associated with a non-MS demyelinating disease consistent with MOGAD when compared with the MOG-IgG–negative patients and controls (table 1): pattern α1β1 (PPV 94.5%, 95% CI 86.7 to 97.9), pattern α1-3β1 (PPV 95.3%, 95.3% CI 87.1 to 98.7), and pattern α1-3β1-3 (PPV 93.8%, 93.9% CI 85.2 to 97.6). This evidence concerns the gene MOG and demyelinating disease.