CHMP2B and Cognitive impairment: In this study, we generated two additional FTLD mouse models harboring mutation of TDP43 (TDPN267S-KI) or CHMP2B (CHMP2BQ165X-KI) (Fig S10A–D), which reproduced human FTLD-TDP or FTLD-UPS pathology (Fig S11) and cognitive impairment (Fig S12).