Analysis of the corneal endothelium from the FECD patients showed enlargement of rough ER and upregulated UPR markers, including the α subunit of the eukaryotic initiation factor 2 (eIF2α), a glucose-regulated protein and a C/EBP homologous protein (CHOP) [55]. The gene discussed is DDIT3; the disease is Fuchs endothelial corneal dystrophy.