On average, late-onset FECD manifests in the fifth decade of life and implicates rare mutations in solute carrier family 4 sodium borate transporter member 11 (SLC4A11, MIM 610206) [9, 10], transcription factor 8 gene (TCF8, MIM 189909) [11], transcription factor 4 gene (TCF4, MIM 602272) [12], lipoxygenase homology domains 1 (LOXHD1, MIM 613072) [13] and ATP/GTP binding protein like 1 (AGBL1, MIM 615496) [4]. The gene discussed is TCF4; the disease is Fuchs endothelial corneal dystrophy.