Although multifocal necrosis was found in peripheral organs such as the liver, vasoactive cytokines including IL-6 and TNF-α affect blood vessel permeability and vascular tone [51, 54], which suggests that excessive production of IL-6 and TNF-α increases vascular leakage in IFN-I signal-incompetent mice, one of the hallmarks of hemorrhage diseases [51, 54]. This evidence concerns the gene TNF and hemorrhagic disease.