The DPB1*13:01 is linked with a variety of DRB1 alleles with low linkage disequilibrium value, i.e., DRB1*01;01, 15;01, 04;06, 11;01, and 12;01 in Japanese, suggesting that association of DPB1*13:01 with anti-topo I antibody-positive SSc is independent of the DRB1/B5 allele association with production of anti-topo I antibody. This evidence concerns the gene HLA-DPB1 and systemic sclerosis.