There were some contradictory findings in terms of the STAT4 SNP associations with SSc susceptibility: association with limited cutaneous SSc (lcSSc), but not with dcSSc in European Caucasian cohorts [28, 46, 48, 49], while association with dcSSc and anti-topo I antibody in Chinese cohort [29]. The gene discussed is STAT4; the disease is systemic sclerosis.