EXOSC10 and systemic sclerosis: Many lines of evidence have shown that individual SSc-related autoantibodies have associations with different HLA class II alleles and haplotypes, including ACA with the DRB1*01;01, DQB1*05;01 haplotype, anti-RNA polymerase III with DRB1*04;01/*04;04, anti-PM-Scl with the DRB1*03;01, DQB1*02;01 haplotype, and anti-U1RNP with the DRB1*04;01, DQB1*03;02 haplotype [94, 98, 102].