In fact, BV2 microglia-like cells treated with CML-AGE, a canonical RAGE ligand present in the ALS spinal cord, demonstrated a RAGE-dependent increase in Il1a and the DEG identified by RNA-seq Malat1. Malat1 has been linked to the regulation of pro-inflammatory responses of peripheral macrophages. This evidence concerns the gene AGER and amyotrophic lateral sclerosis.