While RAGE is expressed in multiple cell-types in spinal cord; the findings that RAGE overlap with microglia is increased in SOD1G93A mice and in a subset of human patients with higher AGER expression, alongside the spatial transcriptomic analyses, implicating the AGE-RAGE pathway alteration in glia, suggested it was logical to probe potential roles for microglia RAGE in ALS-like pathology in the SOD1G93A mouse model. Here, AGER is linked to amyotrophic lateral sclerosis.