TRIM37 and cancer: Furthermore, TRIM37 was also reported to dysregulate in multiple human cancer such as glioma [12, 13], gastric cancer [14], colorectal cancer [15, 16], lung cancer [17, 18], and hepatocellular carcinoma [19–21], and served as a oncoprotein via several classic signals including Wnt/β-catenin, MAPK/ERK, PI3K/Akt, NF-κB as well as epithelial-mesenchymal transition (EMT) process.