TUG1 and osteosarcoma: Consistently, another study by Yang GH et al. [109] showed that miR-425-5p overexpression could inhibit osteosarcoma invasion and migration through directly binding to metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and TUG1, and blocked their activation of Wnt pathway both in vitro and in vivo [109].