At present, with regard to the risk factors of APL related thrombotic events, limited research results showed that they could be related to high leukocyte, CD2/CD15 positive, FLT3/ITD positive, PML/RARa fusion gene variant, retinoic acid syndrome, high platelet count and male [16–18]. This evidence concerns the gene FLT3 and acute promyelocytic leukemia.