Similar to our study, Wells et al. reported similar blood Pb (1.13 μg/dL) levels in a cross-sectional study of 1788 children and no association with asthma, atopic asthma, or general atopy, however, an increase in blood Pb [35] resulted in a significant increase in IgE and eosinophils [11.1% (95% CI 5.6, 16.9) and 4.9% (2.3, 7.6) per 10 μg/L Pb]. This evidence concerns the gene IGHE and asthma.