Interestingly, EGFL8 expression level in high-metastatic liver cancer cell line HCCLM3 was obviously lower than low-metastatic liver cancer cell lines HepG2, in which the expression level of EGFL8 was also lower than almost non-metastatic liver cancer cell lines Hep3B, suggesting the involvement of EGFL8 in metastasis of liver cancer cells (Fig. 2a). Here, EGFL8 is linked to liver cancer.