In a recent study, we showed the upregulation of epidermal growth factor-like domain 7 (EGFL7), a critical gene in vascular tube formation during embryogenesis [11], in HCC tissue samples and elucidated a novel role of EGFL7/FAK/ EGFR signaling pathway in metastasis of HCC, which firstly evidenced the involvement of a member of EGFL gene family in HCC [12]. This evidence concerns the gene PTK2 and hepatocellular carcinoma.