On the other hand, the apoptosis level increased in HCCLM3EGFL8 cells than HCCLM3Vector cells (6.08% ± 0.11% versus 9.11% ± 0.16%, P < 0.001) and decreased in Hep3BshEGFL8 cells than Hep3BshCtrl cells (2.77% ± 0.07% versus 4.60% ± 0.13%, P = 0.001; Fig. 2f), implicating a slightly promotive effect of EGFL8 on apoptosis of liver cancer cells. The gene discussed is EGFL8; the disease is liver cancer.