To explore the prognostic implication of EGFL8 expression in HCC, we divided all 102 cases of HCC patients into low EGFL8 expression group (n = 51) and high EGFL8 expression group (n = 51) according to the results of RT-qPCR and compared the overall and progression-free survival between these two groups. This evidence concerns the gene EGFL8 and hepatocellular carcinoma.