As the only know paralog of EGFL7, epidermal growth factor-like domain 8 (EGFL8) shares the same overall domain structure with EGFL7 such as an EGF-like domain, a Ca2+ binding EGF-like domain, and a N-terminal signal peptide [11, 13], which led us to hypothesize that EGFL8 may also be involved in human cancers just like EGFL7. This evidence concerns the gene EGFL7 and cancer.