TCOF1 and hepatocellular carcinoma: The results demonstrated that these genes were altered in 50 samples out of 357 HCC patients (14%) and the amplification of BRCA1 was the largest frequent copy-number alteration Fig. 6B. In order to further analysis the expression of these 8 RBPs, immunohistochemistry results from the HPA database to illustrate that SNRPD1, IARS, BRCA1, EZH2, RUVBL1, TST, TCOF1, and AZGP1 were significantly increased in tumor tissues Fig. 7.