The results demonstrated that these genes were altered in 50 samples out of 357 HCC patients (14%) and the amplification of BRCA1 was the largest frequent copy-number alteration Fig. 6B. In order to further analysis the expression of these 8 RBPs, immunohistochemistry results from the HPA database to illustrate that SNRPD1, IARS, BRCA1, EZH2, RUVBL1, TST, TCOF1, and AZGP1 were significantly increased in tumor tissues Fig. 7. Here, IARS1 is linked to hepatocellular carcinoma.