AKT1 and alcohol dependence: In addition, KEGG-GSEA analysis showed that DEmRNAs gene sets enrich in Human papillomavirus infection, PI3K-Akt signaling pathway, Alcoholism, Neuroactive ligand-receptor interaction, Cytokine-cytokine receptor interaction (Fig. 2C, E; adjust p < 0.05; Supplementary Material 3).