In summary, our study demonstrated that lncRNA H19 could induce immune dysregulation of BMMSCs in SLE through inhibiting proliferation and migration and inducing apoptosis of BMMSCs, suppressing proliferation of Treg cells, and promoting the conversion of Treg cells to Tfh cells by directly inhibiting IL-2 production and provided novel treatment targets for SLE treatment. Here, IL2 is linked to systemic lupus erythematosus.