GRN and neuronal ceroid lipofuscinosis: Interestingly and corresponding to what has been observed with SQSTM1, while heterozygous mutations in GRN lead to frontotemporal degeneration later in life, homozygous GRN mutations cause a neurodevelopmental disorder with features similar to a lysosomal storage disorder or a neuronal ceroid lipofuscinosis (NCL11) [169].