Another group of conditions that show considerable overlap with EPG5-related Vici syndrome are Chediak-Higashi syndrome (CHS) [198] and related primary immunodeficiency syndromes, with common features of hypopigmentation, immune defects, variable neurological involvement, and, in some cases, a vacuolar myopathy. The gene discussed is EPG5; the disease is Chédiak-Higashi syndrome.