Of note, heterozygosity for mutations in the lysosomal enzyme GBA (glucosylceramidase beta), the gene recessively mutated in Gaucher disease (GD), is the most common genetic risk factor for PD and associated with autophagic impairment, emphasizing the intimate crosstalk between autophagic and lysosomal pathways [158,159]. This evidence concerns the gene GBA1 and Parkinson disease.