Interestingly, a missense mutation in WDFY3 has been found to have the opposing effect and cause hereditary primary microcephaly [119] and reduced brain size in humans and a corresponding Drosophila model, suggesting that WDFY3 plays a general role in determining correct brain size, probably through attenuation of WNT signaling through removal of DVL3 (disheveled segment polarity protein 3) aggregates [119]. Here, DVL3 is linked to Primary microcephaly.