Based on the assumption that multisystem disorders linked in the same molecular pathways do share a recognizable “clinical” signature, a reverse search on Human Dysmorphology databases applying the key features of EPG5-related Vici syndrome reveals indeed a number of clinically similar conditions due to mutations affecting proteins that are implicated in cellular trafficking processes in a wider sense, but that may also give rise to secondary autophagy abnormalities. Here, EPG5 is linked to Vici syndrome.