Impaired autophagic flux and accumulation of autophagosomes in EPG5-related Vici syndrome closely resembles the histopathological findings in lysosomal storage disorders such as GM1 gangliosidosis, Niemann-Pick disease type C1 (NPC1), and the neuronal ceroid lipofuscinoses (NCLs) [182,183]. Here, EPG5 is linked to Niemann-Pick disease, type C1.