Different forms of ALS (and/or of frontotemporal dementia [FTD] with overlapping clinical features) have also been linked to heterozygous dominant mutations in VCP encoding valosin-containing protein (FTDALS6) [164] (also implicated in inclusion myopathy with Paget disease of the bone and FTD [165]), CHMP2B encoding charged multivesicular body protein 2B (FTDALS7) [166], and GRN encoding progranulin [167]. The gene discussed is GRN; the disease is bone Paget disease.