Our functional enrichment of AIM1L-related genes indicated that AIM1L and its-related genes might involve in cell proliferation, cell migration, and signaling pathways, namely, extracellular matrix organization, ECM-receptor interaction, calcium signaling pathway, etc. Since tumorigenesis roles of AIM1L in human cancers have not been reported in details, absent in melanoma 1 (AIM1) has been studies in various human malignancies [48–50]. This evidence concerns the gene CRYBG2 and cancer.