Inhibition of cyclooxygenase-2 (COX-2) in a mouse model of melanoma stimulated tumor rejection, driven by IFN I production by innate immune cells, and increased natural killer cell recruitment and dendritic cell activation (Bonavita et al., 2020; Böttcher et al., 2018; Zelenay et al., 2015). The gene discussed is PTGS2; the disease is melanoma.