As a support, Sasaki et al. report increased expression of LC3 and p62 by IHC in biliary intraepithelial neoplasia (BilIN-1/2 and BilIN-3) and invasive CC in comparison to normal bile ducts, suggesting that an incomplete autophagy is related to the occurrence and development of CC [16]. Here, MAP1LC3A is linked to cholangiocarcinoma.